I always thought abou T Virus + Las Plagas, even before the first information about RE5 were released... I think it would be a great plot if Wesker and his new Umbrella were experimenting the new "toys" in Africa, where no one cares about the people.
Billy didn't die.. Rebecca said he died so that the guy could go free... that's why I think it woudn't make sense if Billy returned... he's sentenced to death, and is "dead". If he comes back, he could be arrested and killed for real o.o
Didnt Billy Die though?
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