Saying Chris was the only important protagonist is like saying Aragorn was the only person who mattered in Lord of the Rings.
As for characters not being born, I guess you could say that about any character in the series. If we wanted to be really pissy about it, we could say that if the universe was never created then there would be no series. If Shinji Mikami's parents didn't share that fateful night in Osaka during a thunderstorm, then maybe just maybe we wouldn't have seen RE? And even better, nothing would have happened. No Umbrella, no Progenitor, no Resident Evil. You and I wouldn't be sitting here right now having this ridiculous conversation about a ridiculous series.
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