T-Virus

[Karui]

As a research project I chose viruses as my subject. While I did this research I happened to remember that in Wesker's report that the T-Virus was originally a strain of ebola virus. Is there any kind of information on what other agents were used to make progenitor? Oh, and you might find it interesting to know that there are four different strains of ebola virus. Two of them only affect animals and plants. The most dangerous strain causes blood veins to harden and has an 85% fatality rate. I'm not sure about you guys, but when I found this out, it scared the shit out of me. Do you possibly think there is a real T-Virus out there?

[Canas Renvall]

Do you possibly think there is a real T-Virus out there?

No. Why, you ask?

Ask TheSelfishGene. Anything he says regarding microbiology is law.

[Darkmoon]

It's not impossible that something could take over a person and spread via a bite. Rabies springs straight to mind. There's no reason a nastier variation of that couldn't come into being that destroyed all higher brain functions and made people vicious attack anyone they saw. But kill them and reactivate the body? While nothing is impossible I think we can list that one under fairly unlikely.

[Beef_jerky_yo]

actually back in jr high, we learned about virus called a T something virus, and the video called it T virus for short. It made people bleed to death or something. I think the breakout was in south america. All I can remember was I got in trouble for laughing out loud when they mentioned that hundreds of people died from the T virus.

And of course, I can't find any information on it because google-ing T Virus only brings up Resident Evil.

[Deadbeard]

Well you don't have to worry about people coming back from the dead as a virus requires living cells to replicate in, and that kind of mutation would simply kill whomever it infected rather than causing massive developmental changes like extra arms or what have you in a fully grown adult.

[Karui]

I ask, because I always have thought the idea of the T-Virus was interesting and since there is actually science explained behind it in files and such, I kind of have to wonder if it's possible. I heard a crazy rumor that HIV/AIDS wasn't as deadly when it first came here, but due to scientists genetically altering it, it became what we know today. As far as re-animation goes, electrical waves are going on in the brain for a long time ( a month, I think) after death. So, is it not possible that a virus can use that to not only re-animate, but also control it's host?

Edit: I seriously doubt a virus could cause mutation though.

[TheSelfishGene]

Ask TheSelfishGene. Anything he says regarding microbiology is law.

Haha cheers.

All that's known about progenitor is that it was isolated from sonnentropes. I don't know of any viruses that cross from plants to animals, but there could be. Viruses are usually specific for their hosts.

As for a real life T virus, probably never be anything like it. The zombies are actually still living people (the only real problem is the zombies getting out of their graves in RE3, but I guess you could say that it's fresh graves?). So their cells still have requirements. still need to be 'living'.

From unfortunate people who've had accidents it's known that there are certain parts of the brain that people can do without (and still be alive). And zombies aren't too clever. But what zombies would still needs is working circulation, because they'd still need oxygen. They also need to physically be able to move. Resident Evil isn't so bad for this, but in alot of zombie movies you see broken bones and disconnected muscles - and with things like this zombies would obviously not be able to use their limbs. Even if they don't feel the pain, they still need the mechanical support.

Even if you shot at a zombie in the chest, blood would fill it's lungs and it wouldn't be able to breathe, and that it would be pretty much over like any other human. A virus wouldn't be able to overcome these problems.

Parasites CAN control host behaviour. But I don't know about something like you'd see in RE. From what examples I've heard it's only really simple behaviours. And I don't know of any parasite that's eusocial (or even social) like las plagas.

I seriously doubt a virus could cause mutation though.

They can and do. Cervical cancers can be caused by a virus, and there's now a vaccine against it. But viruses that mutate things mostly only ever interrupt normal proceedures (which often results in cancer), rather than actually giving anything a new function.

[nemesiswontdie]

Parasites CAN control host behaviour. But I don't know about something like you'd see in RE. From what examples I've heard it's only really simple behaviours. And I don't know of any parasite that's eusocial (or even social) like las plagas.


They can and do. Cervical cancers can be caused by a virus, and there's now a vaccine against it. But viruses that mutate things mostly only ever interrupt normal proceedures (which often results in cancer), rather than actually giving anything a new function.

DING DING DING WE HAZ A WINNER!

[Karui]

So, you're saying that the zombies from RE are unlikely to ever happen, but zombies from 28 days later are more realistic? I thought of the beginning scene when they shot those zombies through the chest when you mentioned it. As to what I was saying about the ebola virus, I was really generalising. There are four different strains. One of them affects human and has an 85% fatality rate. The other two separately affect plants and animals. Then, the fourth also affects human, but has 35% fatality rate. You mentioned vaccines...is it possible to vaccinate a virus? They rapidly mutate unpredictability by breeding with white blood cells. Then again, you did say vaccine not cure. Does anyone know anything about the HIV/AIDS thing though? I thought it would be possible to create a similar virus, by maybe fusing virus DNA, etc. Just think how deadly it would be if ebola and HIV/AIDS were fused. By the way, thanks for your input.

[nemesiswontdie]

Idk if I'm reading this wrong (I'm tired) but I think you're trying to say that you want to infuse the T-virus with HIV/AIDS?

ummm....


How am I supposed to get that virus? Fuck a zombie?

[TheSelfishGene]

Yes. There are many vaccines against viruses.

I've watched a bit of this video, and it looks to be quite good. What you should listen to in particular is the 'adaptive immune system/response'.
Viruses like HIV actually change shape faster than the adaptive immune system can keep up with, and that's why it can't be completely removed from the body.

Unlike in Resident Evil, you can't just fuse viruses together to make superviruses. It's not how it works at all. I'm not sure what ebola has, but HIV doesn't even have DNA.
If you were infected with both HIV and Ebola, then the ebola would probably kill you long before HIV comprimises your immune system and you get AIDS.

[REmaster]

^ For sure, some people don't advance to the stage of full blown AIDS as long as twenty years after they contracted HIV. Sneaky.

[OKeijiDragon]

Idk if I'm reading this wrong (I'm tired) but I think you're trying to say that you want to infuse the T-virus with HIV/AIDS?

ummm....


How am I supposed to get that virus? Fuck a zombie?

Essentially, that would be necrophilia right?

[aris13]

How am I supposed to get that virus? Fuck a zombie?

Or let the zombie spit into your mouth.

[Enetirnel]

Hey Gene, quick question following on from Karui bringing up Ebola...

Now, I'm just going off the top of my head/memory on this. So, just going out on a limb here...

Honestly put, I have a bad memory when it comes to biology overall, however virology is quite interesting to me. So, my apologies for whatever I screw up on these questions as I'm just writing this up on studies/experiments and general reports on the strain findings, naming and so-on that I've read in the past. ;

Ebola and Marbug are the two main Filoviridae, with five known subtypes - Zaire virus, Sudan ebolavirus, Reston ebolavirus, Cote d'Ivoire ebolavirus and Bundibugyo ebolavirus.

Considering that the Lake Victoria Marburgvirus was being found within Megabats/Fruit Bats/Flying Foxes outside of primate infection and eventually caused outbreaks with VHF symptoms over a time-frame, the source of the Filoviridae originally being suspected as being of plant origin (can't remember who wrote the paper, was based on observed cycles between a particular plant's flowering periods to Ebola outbreaks as well a few other things) back in the 90s if my memory is correct.

Now, considering the general diet of a Megabat and that about three or four species of them are known carriers (without symptoms) of Ebola, Marburg and other viruses that can be transferred to other animals as well as humans (in some species - Rabies is a common disease carried by them).

Other Ebola, anti-bodies were found in Guinea Pigs around Zaire and an Ebola-like particle was if my memory is correct, either found and stimulated within a particular type of insect - which also have similar diets to that of the Megabat, although Dr. Swanepoel's study with 24 plants injected with the virus failed in order to find an origin point (although, it was recorded that 13 died due to being physically injected with the virus) within plants, so that's left as an unsolved point of origin and/or infection considering the general diets of most strain carriers.

With those, could it be possible that the point of origin is actually plants - carried by vectors feeding, breeding and eventually building anti-bodies against the particular strains only to be transferred to primates', humans - similar to that of the RE5 Sonnentrope isolation and cultivation?

Of course, considering that Ebola is an RNA virus and that a new strain was found in 2007 and confirmed in 2008 that is 30% different to the original strain could mean that it may have rapid RNA mutations as seen in other RNA viruses having high mutation rates.

Considering the general symptoms over the course of the early stages of infection, with the HMF being a main cause of the outbreak - in some cases, the rapid blood loss and/or pressure on the brain can impact the infected into well... dulling them down a tad and due to to the rapid cell division pumping the body full of the virus and recorded in longer periods of infection - a carrier/infected person's body may actually begin to rot after the circulatory system is overloaded and on the overall - the circulation is rather well... screwed by the amount of infected cells against their division rate.

The lack of general thought, has been seen with a general thought "Feeling sick. Go to city, see doctor." leading to the person coughing, sneezing or even bleeding at that point allowing viral-filled particles within bodily fluids to spread out due to the VHF caused.

(On the fluid comment, personally, my Mother suffers from Hydrocephalus, and I had to assist the doctor at the time, she had to have it emptied not that long ago and had shocking memory and wouldn't always respond until fluid was removed before she was able to fully respond and coordinate herself properly).

Essentially, somewhat similar to the general effects shown within Biohazard? Considering that the initial strains' incubation period could last from 2 to 21 days, however there is also the newest strain that can go up to 42 (or possibly more) days. Within that time period, if misdiagnosed from the initial symptoms and pathogens being spread (say, a busy doctor's office from someone nearby who has either come across a carrier OR a point of origin) could theoretically cause an outbreak if the virus has undergone a period of mutation to a similarity of the T, G outbreak we seen within Raccoon (especially if you consider the leeches containing the virus for such a period of time, which could make it a couple of strains of T, followed by the later G variant)?

Another question, what if a particular strain was to target and/or additionally infect Mitochondria (following the idea presented by Hideaki Sena in his novel Parasite Eve of mitochondrial mutations) combined with the RNA having a higher mutation rate, Ebola having a rapid division.

Theoretically, if a new strain was to do this and be spread out by a single carrier and it continued to mutate at a rapid rate and cause mutations from base Mitochondria - could it be actually possible to cause further mutation outside of Cancer and/or tumors, possibly similar to the G-Virus' initial point of origin from being a mutation found within Lisa Trevor's body (with her age being quite young, aging process wouldn't essentially be causing the level of cell destruction we see around the age of 25-26 years of age, with a natural anti-body response to T causing a mutation when the parasite is introduced, additionally with it adapting to Mitochondria, with it's mtDNA being connected to aging as well as general species and the amount of targeted specific sequences that could be contained within a singular infection differing between the gender inheritance (possibly, could explain Wesker's lack of visual aging, may have featured a variant with T-Veronica/Alexia over time additionally as well as repair on the genetic level)?

However, it would probably be a multi-infection to cause something similar to the Biohazard zombies in comparison to the 28, [REC] types...

Sorry, just a general thought - hopefully I've worded this out alright (kinda falling asleep as I write this), but I think this is what Karui was originally getting at. ;