I don't think it contradicts anything. Wesker could very well have had a girlfriend (more a sex-friend knowing good old Al') for a brief period, during his time as an intelligence officer for example. And as soon as the girlfriend wanted to be closer to him, he left her. Who knows?
For sure, but Wesker is the only person with a "cursed blood" they know of for unknown reason (Ada's organisation perhaps). So it's natural for them to chase his son rather than some random people they aren't aware of.
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